Seroquel is an antagonist at a number of neurotransmitter receptors in the brain: serotonin 5HT1A and also 5HT2 (IC50s=717 & 148nM, respectively), dopamine D1 as well as D2 (IC50s=1268 & 329nM, specifically), histamine H1 (IC50=30nM), and adrenergic α1 and α2 receptors (IC50s=94 & 271nM, respectively). Seroquel has no substantial affinity at cholinergic muscarinic as well as benzodiazepine receptors (IC50s > 5000 nM).
Seroquel Bipolar II. Seroquel Quetiapine.
Quetiapine fumarate tactics is primarily due to the moms and dad drug. The multiple-dose pharmacokinetics of quetiapine are dose-proportional within the recommended scientific dosage range, and also quetiapine accumulation is predictable after a number of dosing. Removal of quetiapine is generally using hepatic metabolism with a mean terminal half-life of regarding 6 hrs within the proposed scientific dose range. Steady-state concentrations are anticipated to be accomplished within two days of dosing. Quetiapine is unlikely to meddle with the metabolic rate of medications metabolized by cytochrome P450 enzymes.
At steady-state the pharmacokinetics of the moms and dad compound, in teenagers and also youngsters (10-17 years old), were similar to adults. When changed for dosage and also weight, AUC and also Cmax of the moms and dad compound were 41 % as well as 39 % lower, respectively, in children as well as adolescents compared to in grownups. For the energetic metabolite, auc, norquetiapine as well as cmax were 45 % and also 31 % higher, respectively, in children and teenagers than in grownups. When adjusted for dosage as well as weight, the pharmacokinetics of the metabolite, norquetiapine, was comparable in between youngsters and also teens as well as adults [view Use in Specific Populations (8.